Ralph D’Agostino, Sr.

 Dr. D'Agostino is Professor of Mathematics/Statistics, Biostatistics and Epidemiology at Boston University (Ph.D., Harvard, 1968).  He is also the Director of the Statistics and Consulting Unit and the Executive Director of the MA/PhD Program in Biostatistics.

His major fields of research are clinical trials, epidemiology, prognostics models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research.  He is in the top 1 percent of the Most Cited Authors in Clinical Medicine (2014) and in World’s Most Influential Minds In Clinical Medicine (2015)(by Thomson Reuters).

Dr. D'Agostino has extensive experience (since the 1980s)developing cardiovascular risk prediction models which have been used in Treatment Guidelines sponsored by the NIH and American Heart Association and also web based models for general consumer use.

He is a Fellow of the American Statistical Association and the American Heart Association and has been with the Framingham Heart Study since 1981 and was Co-Principal Investigator of the Core contract and Director of Data Management and Statistical Analysis for the study for over 30 years.

He is a Special Government Employee (SGE) to the United States' Food and Drug Administration (FDA. He has been affiliated with the FDA’s Center for Drugs Evaluation and Research (CDER) since 1974 as an Expert Consultant to the Biometrics Division, the Over-the-Counter Drugs Division, the Oncology Drugs Division, the Cardiovascular-Renal Drugs Division and the Gastrointestinal Drugs Division. He is also a consultant to the Device Division. Further, he has served on a number of Advisory Committees and was the Chair of the Nonprescription Drugs Advisory Committee (NDAC). He has twice been the recipient of the FDA's Commissioner's Special Citation (1981 and 1995). In December 2015 he served as Acting Chair on the Psychopharmacologic Drugs Advisory Committee (PDAC).

He has over seven hundred publications in peer reviewed journals and is co-author/editor of ten books including: Factor Analysis: An Applied Approach, Goodness-of-Fit Techniques, Mathematical Models in Health Services Research, Practical Engineering Statistics, Tutorials in Biostatistics (2 volumes), Introductory Applied Biostatistics, Pharmaceutical Statistics Using SAS: A Practical Guide, Managing Cardiovascular Risk, Therapeutic Strategies in Cardiovascular Risk, and Missing Data in Clinical Trials.

Presently, he is an Editor of Statistics in Medicine, Statistical Consultant on the editorial board of the New England Journal of Medicine, and on the editorial board of Current Therapeutic Research. He is also an Editor of the Wiley Encyclopedia of Clinical Trial and Associate Editor for the Encyclopedia of Biostatistics. He has served on the editorial boards of the American Statistician, Journal of the American Statistical Association, Biostatistica, and Health Services and Outcomes Research Methodology.

Publications on PubMed

Therapeutic Areas


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